investigators title

Dr. Leocadio Rodriguez Mañas (Md, PhD) is the Head of the Department of Geriatrics at Hospital Universitario de Getafe (Madrid), President of the Research Committe at Hospital Universitario de Getafe and Professor "ad honorem" of the Department of Medicine (School of Medicine, Facultad de Medicina de la Universidad AutOnoma de Madrid). He is the past Director of the Foundation for Biomedical Research at the Hospital Universitario de Getafe.

Co-ordinator of the Spanish Collaborative Research Network on Aging and Frailty - RETICEF (Ministry of Science and Innovation), Co-director of the epidemiologic study Toledo Study on Healthy Ageing that is been carried out on 2.845 community-dwelling elder people, founding member and President of the Academia Latinoamericana de Medicina del Adulto Mayor (ALMA), member of the European Academy for Medicine of Aging and Secretary of the Special Group of Interest in Diabetes of the European Union Geriatric Medicine Society.

Member of Evaluating Committees of several Spanish public research organisms. Advisor of the PAHO (WHO) in topics related to Health in Old Age.

Principal Investigator in 23 research projects both public agency- and industry-sponsored. Research background and expertise: clinical investigation in human vascular (endothelial) ageing and mechanisms of vascular damage in diabetes. He has published more than 110 original manuscripts in peer reviewed journals (British Medical Journal, Ageing Cell, Circulation, Circulation Research, Hypertension, J Hypertension, Diabetologia, J Clin Endocrin Metab, J Gerontol, Br J Pharmacol, J Nutrition, Med Clinica, Rev Esp Cardiol, etc), and is author of 54 books and book chapters. He has participated in performing Technical Reports on several aspects of ageing and on diabetes in the aged.


The organization SERVICIO MADRILEÑO DE SALUD (SERMAS) is the administrative and management structure that integrates every public hospital and every public health service of the Madrid Regional Health System. SERMAS is the project coordinator, and delegates' authority to Hospital's General Director to manage research projects.

SERMAS is a public organization that includes 31 hospitals and some other primary health services. There are Foundations for Biomedical research from some of the Hospitals that act as third parties linked to the Hospitals. Collaboration between SERMAS (Hospital) and Foundations is carried through a prior collaboration agreement, by means of which the latter handles the financial and administrative aspects of the Hospital' involvement in research projects, including all issues relating to the employment and payment of additional personnel, purchase of equipment and consumables, etc. The Foundation is situated in the premises of the Hospital.

The "Fundacion para la Investigacion Biomedica del Hospital de Getafe" is the third party linked to Hospital Universitario de Getafe order to manage the administrative tasks of the Hospital.

The Hospital has a prior agreement with this non-profit foundation by means of which the latter handles the financial and administrative aspects of the Hospital' involvement in research projects, including all issues relating to the employment and payment of additional personnel, purchase of equipment and consumables, etc. The Foundation is situated in the premises of the Hospital."

Dr. Leocadio Rodriguez (project coordinator) is the head of the Department of Geriatrics at Hospital Universitario de Getafe, and coordinator of the Spanish Collaborative Research Network on Aging and Frailty -RETICEF funded by the "Instituto de Salud Carlos III", which main goal is the research activities in ageing and frailty, developing excellence action both in research and education to support the better understanding of mechanisms that are implied in those processes.

The personnel who will be more directly involved in the project will be composed by: Dr. Leocadio Rodriguez; Dr. Cristina Alonso; Dr. Marta Castro; Ms Noelia Targadila; Ms. Elia Moreno y Ms Belen Riquelme.




Dr Catherine Féart is a post-doc researcher at the Research Center INSERM U897 (National Institute on Health), University of Bordeaux, France. She has spent 4 years (from 2006/01/01 to today) in the INSERM U897, in the team "Epidemiology of Nutrition and Food Behaviours" directed by Dr P. Barberger-Gateau. She has a PhD in Food Science and Nutrition from University Bordeaux 1 (since 2004) and a complementary training in epidemiology; mainly in the field of nutrition and brain aging. Her topic was the research of the nutritional determinants of pathological brain aging. She participates presently in the COGINUT project as assistant of the coordinator. The impact of nutritional habits, as dietary pattern or assessed by biological plasma concentrations on pathological brain aging, mainly late-life depression, cognitive decline and dementia, has been recently published in peer reviewed journals of high impact factor, such as the Journal of the American Medical Association or the American Journal of Clinical Nutrition.




The Research Center `Epidemiology and Biostatistics' INSERM U897 is an institution of 7 pooling teams (more than 50 permanent researchers) with different topics; all of them having public health perspectives ( This Research Center provides excellent working facilities. The centre has long experience of research of aging and the groups have expertise in epidemiological and clinical studies, neuroimaging, and experimental studies. The centre provides opportunities for collaborative clinical and basic laboratory work, and has access to the most modern techniques and methods. A multidisciplinary perspective has been guaranteed by the presence of scientists from different fields. This facilitates both the study of complex aging processes from different perspectives and the dispersion of research results into care and policy. As other indicators of scientific quality, Research Center INSERM U 897 researchers

(a) have arranged and been invited to many international conferences,
(b) have been successful in securing external funding at the major research councils,
(c) have attracted post docs and visiting scientists from many countries, and
(d) have established collaborative links with many highly visible aging researchers in France and internationally.

In addition to the team 'Epidemiology of nutrition', there are notably the teams 'Epidemiology and Neuropsychology of Aging' (directed by JF Dartigues), and 'Biostatistics' (directed by D; Commenges) with which we are in closely collaboration since many years. For instance, we started the PAQUID Study in 1988 and The Three-City (3C) Study in1999; two prospective ongoing cohort on older persons. The 3C study (principal investigators A. Alperovitch, C. Tzourio (INSERM U708) and JF. Dartigues (U897); promoter (SPED University Bordeaux 2) focused on vascular factors in dementia in French elderly (N=9294). There is also a collaborative research program named COGINUT (COGnition, anti-oxidants, and fatty acids: Interdisciplinary approach of the role of NUTrition in brain aging), managed by P. Barberger-Gateau and funded by the French National Agency for Research, in the frame of the 3C study. The COGINUT study is presently the largest biological, nutritional and cognitive database in a general elderly population in France.

As the Institute of Public Health, Epidemiology and Development (ISPED, with which INSERM U897 is linked) is considered as the "Bordeaux School of Public Health", there is a large offer of training in first year of master (public health) and in second year of master (research in epidemiology, biostatistics, or professional training).

The personnel who will be more directly involved in the project will be composed by Dr. Catherine Feart, Dr. Pascale Barbeger-Gateau and Alberto Avila Funes.




Professor Mann obtained his BSc in Zoology (1973) from George Washington University, Washington D.C. USA and MSc (1974) and PhD in Physiology (1978) from University College London. He was then appointed to a 4-year postdoctoral research fellowship at Queen Elizabeth College and then a Lectureship in Physiology (1981), Readership in Physiology (1992) and as Professor of Vascular Physiology at King's College London in 1997.

He has served as Chairman and Deputy Chairman of the Executive Committee of The Physiological Society, President of the European Pancreatic Society, Council Member of the Physiological Society, Society for Free Radical Research-Europe, European Society for Microcirculation, Microcirculatory Society USA International Liaison Committee and was recently elected President of the British Microcirculation Society. Professor Mann is an Associate Editor for Free Radical Biology and Medicine, Editor for Free Radical Research, Editorial Advisor for the Biochemical Journal, and serves on the International Advisory Board of Ada Physiologica Sinica. He is currently a member of the Basic Science Panel of Heart Research UK, Board of External Referees for the Biotechnology and Biological Sciences Research Council and College of Experts for the Medical Research Council - Physiological Systems & Clinical Sciences. He has previously served on grant panels of the British Heart Foundation and Guy's Charitable Foundation. At KCL he is closely involved in postgraduate studies and as Head of Graduate Research in the School of Biomedical & Health Sciences is actively involved in establishing research and postgraduate exchange links with universities in China, hosting K.C. Wong/China Scholarship Council PhD Scholars.



King's College London (KCL) is one of England's oldest and most prestigious university institutions: a multi-faculty research-led university college based in the heart of London with over 19,700 students, of whom more than 6,200 are postgraduates. It is ranked as one of the world's top 25 universities. KCL was founded by King George IV and the Duke of Wellington (then Prime Minister) in 1829 as a university college in the tradition of the Church of England. It now welcomes staff and students of all faiths and beliefs. KCL has grown and developed through mergers with several institutions who have their own distinguished histories. These include the United Medical and Dental Schools of Guy's and St Thomas' Hospitals; Chelsea College, Queen Elizabeth College, and the Institute of Psychiatry.

KCL's location in the heart of London and its strength in law, humanities and the social sciences make it a major player in forging links between the arts, culture and universities, and in the development of public policy at national level. Its very broad range of subjects, including also physical sciences and engineering, are increasingly inter-related, notably in fields such as bioinformatics, health policy and medical humanities. King's nine Schools of Study are Arts & Humanities; Biomedical & Health Sciences; the Dental Institute; Law; Medicine; the Florence Nightingale School of Nursing & Midwifery; Physical Sciences & Engineering; the Institute of Psychiatry, and Social Science & Public Policy.

The university offers an intellectually rigorous environment supported by welcoming and caring traditions. King's has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA, and it is now the largest centre for the education of doctors, dentists and other healthcare professionals in Europe and home to six Medical Research Council centres.

The staff and alumni of King's and its constituent institutions made major contributions to 19th-century science, medicine and public life in general. In the 20th century nine people from these institutions were awarded the Nobel Prize.

King's Health Partners hosted a major international conference Academic Health Science Centres: a revolution in healthcare? on 6 March 2009 at the Guy's Campus of King's College London. This one-day event provided the opportunity for Academic Health Sciences Centres (AHSCs) from across the globe to collaborate and share ideas and their understanding of the added value they bring to the patient. Conference external speakers include: Dr Victor Dzau, President and CEO of the Duke University Health System; Dr Michael Klag, Dean, Johns Hopkins Bloomberg School of Public Health; and Sir Alan Langlands FRSE, Principal and Vice-Chancellor, University of Dundee.

Professor Robert Lechler, Interim Director of King's Health Partners and Vice-Principal (Health) at King's College London, will give the welcome address.

To view the provisional programme for further details on the conference content visit the AHSC website. (

Aging Network at KCL - Ageing consists of complex systems at the level of biology, psychology and society. In order to understand the processes of ageing and the nature of old age itself, it is important to bring together learning and research from a number of key disciplines. ARK is uniquely positioned to address the challenges of an ageing world, and provide answers at each level of analysis. This cross-divisional virtual research group brings together ageing scholarship and expertise in several complementary areas:

Geriatric Medicine - At King's, we are at the leading edge of research into the treatment of age-related diseases and conditions, including rheumatoid arthritis and stroke. Our specialist departments pursue research into the causes and treatment of mental health problems in older people, with a number of strong groups working on Parkinson's and Alzheimer's disease and other dementias, depressions and psychoses. We also have established teams concerned with care for the older patient. For example, Professor Irene Higginson and her team in the department of Palliative Care, Policy & Rehabilitation, who have published the WHO guide to Better palliative care for old people.

Cardiovascular Division KCL - Prof GE Mann is one of 35 Principal Investigators in the Cardiovascular Division, School of Medicine at KCL. The Cardiovascular Division is one of the largest Research Divisions within the Health Schools of King's College London and comprises - 160 research workers (including 35 Principal Investigators [Pls] and >60 PhD/MD students) whose work is focused on the mechanisms and treatment of cardiovascular disease.

The Division was recently designated as the 'King's British Heart Foundation (BHF) Centre of Research Excellence' in April 2008 with £9 million funding from the BHF with the aim of promoting cutting edge research and training in cardiovascular research. The Centre brings together a unique range of internationally renowned scientists and clinicians from the Cardiovascular, Randall and Imaging Sciences Divisions who are focussed on basic and applied work that leads to advances in the early diagnosis, prevention and treatment of heart diseases. The Centre is directed by Professor Ajay Shah, BHF Professor of Cardiology at King's, with a Steering Group comprising research theme leads.

The principal aims of the Centre of Research Excellence are to build upon the foundation of existing cardiovascular and related non-cardiovascular strengths at King's to:

(a) provide a highly collaborative, multi-disciplinary environment which catalyses the pursuit of imaginative and innovative cardiovascular research programmes;
(b) place major emphasis on the translation of fundamental laboratory advances to the clinical arena, eventually leading to therapeutic advances in the areas of atherosclerosis, cardiac protection and cardiac failure;
(c) engage noncardiovascular and non-biomedical scientists to direct their expertise to cardiovascular problems; and
(d) deliver outstanding research training and a nurturing environment for clinical and non-clinical scientists.

KCL has a long-standing interest in age-related diseases, supported by two well established research divisions, namely the Wolfson Centre for Age-Related Diseases and Applied Biomedical Research Division (interested in frailty, etc) and the Institute of Psychiatry.



Professor José Viña was born in Valencia, Spain in 1953. After pursuing his studies in Medicine at the University of Valencia, and doing research work under the auspices of Prof Hans Krebs (Krebs cycle) in Oxford, he obtained his PhD in 1976. After teaching Physiology at Extremadura University (Spain) he returned to Valencia and took up his position as Professor of Physiology at the University of Valencia where he still works. Here Prof Viña combines his teaching duties with research work, the latter in two main lines: Ageing and exercise. José Viña leads a successful research group working on different aspects of oxidative stress with whom he has won numerous prizes for research work; he has published widely on glutathione, mitochondria, oxidative stress, free radicals and nutrition.

He has received several honors, like the Boehringer prize for best research work in Biochemistry developed in Spain, the National Research Prize in Biomedicine or the Spanish Society of Geriatrics and Gerontolgy Prize for research in Geriatrics and Gerontolgy. Prof. Viña was made Honorary Fellow of the Academy of Medicine of Torino and Doctor Honoris Causa of the University Of Buenos Aires, Argentina, in November 2008.

Dr. Viña has published more than 200 articles in prestige scientific reviews like Journal of the American medical Association or Nature.




At the beginning of the fifteenth century, the Juries of Valencia compiled studies which were dependent on the city and the church, but they separated again in the year 1416. The foundation of the University of Valencia had to wait until 30th April 1499 when the Constitutions were published, written at the request of the council of Valencia. The bull of Pope Alexander VI in 1501, together with the royal privilege Fernando II a year later, led to the official opening of the General Study of Valencia on 13th October 1502, thus reaching university status and equivalence prerogatives and distinctions.

Initially dedicated to the studies of medicine, humanities, theology and law, it has now become a modern European university, open almost all disciplines in humanities, basic and technical sciences, health sciences, social sciences, and education, as well as research and culture.


The University of Valencia is ranked third or fourth in the Spanish university system with regard to research, according to different international rankings.

Ø The University of Valencia is a pioneer in research with 960 research projects and 95 patents (between 1995 and 2005). In the last budget it dedicated 55 million euros to research grants, guest professors, University of Valencia researcher's and co-financed researchers from other organisations.
Ø Research activity is focused on basic and applied fields and boasts a significant number of researchers and teachers in departments and university institutes.
Ø Research at the University of Valencia benefits society and, in particular, businesses and public administrations through the Office of the Transfer of Research Results (OTRI). This office is responsible for facilitating and promoting collaboration between the world of university research and companies within socioeconomic environment.
Ø The University of Valencia develops other research activities such as it own publications, conferences, and national and international scientific meetings in different disciplines.
 The journal Metode has already published more than 50 issues, and the University of Valencia research bulletin IDia has been added to the list of publications.


Human resources at the University include 3.256 professors and researchers, and 1,706 administration and service personnel. The University enrols the highest number of students among Valencia universities and offers personal attention with a ratio of 14.8 students per professor/lecturer and 28.3 students per administration and service personnel.

The personnel who will be more directly involved in the project will be composed by: Dr. Jose Vina; Dr. Consuelo Borres ans Dr. Juan Gambini.